Taribavirin: potential future in the treatment of hepatitis C

Author:

Farrell Christopher P1,Mercogliano Giancarlo1,Navarro Victor J2,Rossi Simona

Affiliation:

1. Lankenau Hospital, 100 East Lancaster Avenue, Wynnewood, PA 19096, USA

2. Thomas Jefferson University Hospital, 132 South 10th Street, 480 Main Building, Philadelphia, PA 19107, USA

Abstract

Taribavirin is a prodrug of ribavirin, studied as a treatment modality in combination with PEGylated interferon for chronic hepatitis C. Taribavirin is catalyzed to ribavirin by adenosine deaminase, which is ubiquitous within the body. Taribavirin has resulted in significantly lower rates of anemia, the main complication of ribavirin and cause of dose reductions or discontinuation. Previous clinical studies failed to demonstrate noninferiority to ribavirin. However, better results were observed when taribavirin was given as a weight-based medicine, as shown in a recently published Phase IIb study.

Publisher

Future Medicine Ltd

Subject

Virology

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