Generalized chorea associated with subcortical leukoaraiosis of Binswanger type: a case report

Author:

Espiritu Adrian I12ORCID,Saranza Gerard Raimon M13,Anlacan Veeda Michelle M14,Suratos Cezar Thomas R1,Jamora Roland Dominic G1ORCID

Affiliation:

1. Department of Neurosciences, College of Medicine-Philippine General Hospital, University of the Philippines Manila, Manila, 1000, Philippines

2. Department of Clinical Epidemiology, College of Medicine, University of the Philippines Manila, Manila, 1000, Philippines

3. Morton & Gloria Shulman Movement Disorders Clinic & Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, Toronto, Ontario, M5T 2S8, Canada

4. Center for Memory & Cognition, Department of Neurosciences, Philippine General Hospital, University of the Philippines Manila, Manila, 1000, Philippines

Abstract

Binswanger disease (BD) involves injuries to the brain small vessels, resulting to gradually progressive subcortical ischemia. This disorder manifests with dementia, gait abnormalities, upper motor signs and parkinsonism, and presents as extensive, confluent, bilateral cerebral white matter hyperintensities in the MRI. Cases of BD typically manifests with vascular risk factors, such as hypertension and multiple strokes. We report a unique case of a Filipino patient whom we have diagnosed with BD presenting with no cardinal signs of parkinsonism, but with generalized choreiform movement disorder and without a history of hypertension and symptomatic strokes. To our knowledge, this is the first report presenting an adult patient with subcortical leukoaraiosis of Binswanger type associated with a hyperkinetic movement disorder.

Publisher

Future Medicine Ltd

Subject

Neurology (clinical)

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