Critical evaluation of the DNA-methylation markers ABCG1 and SREBF1 for Type 2 diabetes stratification-Reference-Cited by-同舟云学术

Critical evaluation of the DNA-methylation markers ABCG1 and SREBF1 for Type 2 diabetes stratification

Published:2019-06 Issue:8 Volume:11 Page:885-897
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Krause Christin¹,Sievert Helen¹,Geißler Cathleen¹,Grohs Martina¹,El Gammal Alexander T²,Wolter Stefan²,Ohlei Olena³,Kilpert Fabian³,Krämer Ulrike M⁴⁵,Kasten Meike⁶⁷,Klein Christine⁶,Brabant Georg E¹,Mann Oliver²,Lehnert Hendrik¹⁸,Kirchner Henriette¹⁸

Affiliation:

1. Medical Department I, Division Epigenetics & Metabolism, University of Lübeck, Lübeck, Germany

2. Department of General, Visceral & Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

3. Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics & Integrative & Experimental Genomics, University of Lübeck, Lübeck, Germany

4. Department of Neurology, University of Lübeck, Lübeck, Germany

5. Institute of Psychology II, University of Lübeck, Lübeck, Germany

6. Institute of Neurogenetics, University of Lübeck, Lübeck, Germany

7. Department of Psychiatry & Psychotherapy, University of Lübeck, Lübeck, Germany

8. German Center for Diabetes Research (DZD), München-Neuherberg, Germany

Abstract

Aim: Validation of epigenome-wide association studies is sparse. Therefore, we evaluated the methylation markers cg06500161 ( ABCG1) and cg11024682 ( SREBF1) as classifiers for diabetes stratification. Patients & methods: DNA methylation was measured in blood (n = 167), liver (n = 99) and visceral adipose tissue (n = 99) of nondiabetic or Type 2 diabetic subjects by bisulfite pyrosequencing. Results: DNA methylation at cg11024682 in blood and liver correlated with BMI. Methylation at cg06500161 was influenced by the adjacent SNP rs9982016. Insulin-resistant and sensitive subjects could be stratified by DNA methylation status in blood or visceral adipose tissue. Conclusion: DNA methylation at both loci in blood presents a promising approach for risk group stratification and could be valuable for personalized Type 2 diabetes risk prediction in the future.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2018-0159

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