Deliberations about clinical pharmacogenetic testing in pediatric oncology

Author:

Issa Amalia M1234ORCID,Aboushawareb Sarah AE4,Eisenstat David D56,Guilcher Greg MT78,Liu Geoffrey9,Rassekh S. Rod101112,Strahlendorf Caron101112,Tallen Gesche713,Tanoshima Reo1415,Carleton Bruce10ORCID

Affiliation:

1. Personalized Precision Medicine & Targeted Therapeutics Institute, PA 19064, USA

2. Departments of Pharmaceutical Sciences and Health Policy, University of The Sciences in Philadelphia, Philadelphia, PA 19104, USA

3. Centre of Genomics & Policy, McGill University, Montreal, Quebec H3A 0G1, Canada

4. Department of Family Medicine, McGill University, Montreal, Quebec H3S 1Z1, Canada

5. Department of Paediatrics, Murdoch Children’s Research Institute, University of Melbourne, Melbourne 3052, Australia

6. Departments of Pediatrics, Medical Genetics & Oncology, University of Alberta, Edmonton AB T6G 2H7, Canada

7. Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta T3B 6A8, Canada

8. Department of Oncology, University of Calgary, Calgary AB T2N 4N1, Canada

9. Department of Medical Oncology & Hematology, Princess Margaret Cancer Centre, Toronto ON M5G 2C1, Canada

10. Department of Pediatrics & BC Children’s Hospital Research Institute, Division of Translational Therapeutics, University of British Columbia, Vancouver, BC V6H 3V4, Canada

11. YCU Center for Novel & Exploratory Clinical Trials, Yokohama City University, Yokohama, Kanagawa 236-0004, Japan

12. Department of Pediatrics, University of British Columbia, Vancouver, BC V6H 3V4, Canada

13. Pediatric Hematology/Oncology/BMT, BC Children’s Hospital, Vancouver BC V6H 3V4​,​ Canada

14. Department of Pediatric Oncology/Hematology, Charité-Medical School Charitéplatz 1, Berlin 10117, Germany

15. Department of Pediatrics, Yokohama City University, Yokohama, Kanagawa 236-0004, Japan

Abstract

This article summarizes the background, content and outcomes of a special meeting that was convened among oncologists and scientists to discuss the role of pharmacogenetic (PGx) testing in pediatric clinical oncology practice. This meeting provided an opportunity for what the lead author (AM Issa) refers to as the ‘voice of the clinician’ dynamic to be amplified in order to better understand how personalized or precision medicine applications such as PGx testing are adopted and incorporated into clinical settings and what we can learn from the experiences of current and ongoing implementation PGx approaches to further the implementation of precision medicine applications in real-world environments. Group dynamics and clinical experience with PGx testing and return of results shaped the discussion.

Funder

Genome Canada/Genome British Columbia

Canadian Institutes of Health Research

Publisher

Future Medicine Ltd

Subject

Pharmacology,Molecular Medicine,General Medicine

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