Affiliation:
1. Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL 32306, USA
Abstract
The oncogenic potential of Epstein–Barr virus (EBV) is mostly attributed to latent membrane protein 1 (LMP1), which is essential and sufficient for transformation of fibroblast and primary lymphocytes. LMP1 expression results in the activation of multiple signaling cascades like NF-κB and MAP kinases that trigger cell survival and proliferative pathways. LMP1-specific signaling events are mediated through the recruitment of a number of interacting proteins to various signaling domains. Based on these properties, LMP1 is an attractive target to develop effective therapeutics to treat EBV-related malignancies. In this review, we focus on LMP1-interacting proteins, associated signaling events and potential targets that could be exploited for therapeutic strategies.
Cited by
9 articles.
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