Cellular prion protein-mediated protection against influenza A virus infection

Abstract

The cellular prion protein, termed PrPC, is a glycoprotein abundantly expressed in brains and to a lesser extent in non-neuronal tissues including lungs. It was reported that PrPC is expressed by lung epithelial cells in mice, and that it may play a protective role against lethal infection with influenza A viruses (IAVs). This may occur by regulating Cu content and  superoxide dismutase (SOD) activity, eventually reducing oxidative stress in infected lungs. Antioxidative therapeutics have been demonstrated to protect mice from lethal infection with IAVs. Therefore, PrPC might be a new target molecule for development of IAV therapeutics. Here, we introduce the antiviral mechanism of PrPC against IAV infection and discuss perspectives of PrPC-targeting therapeutics against IAV infection.