Plain language summary of a fingerprinting technique to monitor blood cancer

Abstract

What is this summary about? This is a plain language summary discussing the results of our study published in the journal Nanomedicine. The study describes how to improve the detection of blood cancer and chart the progress of recovery/remission to reassure patients living with cancer. What did we do? In our study, we used a new tool called Raman spectroscopy to detect molecules found uniquely in the blood plasma of people with, or recovering from, blood cancer. Our aim was to fine-tune this technique so that it could help doctors better determine if cancer was growing back or not responding to treatment. Gold nanoparticles were used to enhance the signal of these cancer-specific molecules so that Raman spectroscopy (also called nanoSERS) could better identify and expose the cancer in hiding. What is the importance of these findings? We discovered that this new tool (Raman spectroscopy using gold nanoparticles) can detect trace molecules in the blood found only when cancer cells are present or when a person's cancer is returning. This study, which has identified new potential for Raman spectroscopy as an early-screening tool, opens the possibility for the better monitoring of blood cancer. This could mean both less aggressive and fewer treatments for people diagnosed with this disease. This tool may also be useful for people seeking reassurance that their cancer remains dormant or will be identified for treatment sooner if it returns. These findings can also be applied more broadly, such as in helping scientists test the effectiveness of new treatments as they continue to get better at eliminating cancer cells.