<i>IL6R</i> gene polymorphisms and their relation to chronic obstructive pulmonary disease susceptibility in the Chinese population-Reference-Cited by-同舟云学术

IL6R gene polymorphisms and their relation to chronic obstructive pulmonary disease susceptibility in the Chinese population

Published:2022-12 Issue:17 Volume:16 Page:1229-1237
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Wu Haihong¹²^ORCID,He Chanyi¹^ORCID,Fu Yihui¹²^ORCID,Li Xiukuan¹³^ORCID,Zheng Yamei¹²^ORCID,Mo Rubing¹²^ORCID,Zhang Lei¹²^ORCID,Zhao Jie¹²^ORCID,Zhang Bingli¹²^ORCID,Lin Qi¹^ORCID,Xie Tian¹²^ORCID,Ding Yipeng¹²^ORCID

Affiliation:

1. Department of General Practice, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, 570311, China

2. Department of Pulmonary & Critical Care Medicine, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, 570311, China

3. Meitai Health Center of Lingao County, Lingao, Hainan, 571824, China

Abstract

Background: This work was designed to explore the correlation between IL6R polymorphisms and chronic obstructive pulmonary disease (COPD) susceptibility. Methods: Agena MassARRAY was used to genotype five SNPs of IL6R in 498 patients with COPD and 498 controls. Genetic models and haplotype analysis were used to assess the associations between SNPs and COPD risk. Results: Rs6689306 and rs4845625 increase the risk of COPD. Rs4537545, rs4129267 and rs2228145 were related to a decreased risk of COPD in different subgroups. Haplotype analysis revealed that GTCTC, GCCCA and GCTCA contributed to a reduced risk of COPD after adjustment. Conclusion: IL6R polymorphisms are significantly associated with COPD susceptibility.

Funder

Hainan Provincial Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2022-0342

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