Mesoporous silica with precisely controlled pores reduces food efficiency and suppresses weight gain in mice-Reference-Cited by-同舟云学术

Mesoporous silica with precisely controlled pores reduces food efficiency and suppresses weight gain in mice

Published:2020-01 Issue:2 Volume:15 Page:131-144
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Rinde Mia¹,Kupferschmidt Natalia¹,Iqbal Muhammad Naeem²,Robert-Nicoud Ghislaine³,Johnston Eric V³,Lindgren Maria³,Bengtsson Tore¹^ORCID

Affiliation:

1. Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE-106 91, Stockholm, Sweden

2. Department of Material Chemistry, Stockholm University, SE-106 91, Stockholm, Sweden

3. Sigrid Therapeutics AB, Sankt Göransgatan 159, SE-112 17, Stockholm, Sweden

Abstract

Aim: Obesity is a risk factor for cardiovascular disease and diabetes. We aimed to elucidate the effects of distinct mesoporous silica particles (MSPs) supplemented in food on metabolic parameters in obesity. Materials & methods: MSPs with precisely controlled pore size were synthesized, characterized and compared with a control in a C57Bl/6 mouse diet-induced obesity model, studying weight, adiposity, metabolic regulation and food efficiency. Results: The most effective MSPs reduced adipose tissue formation to 6.5 ± 0.5 g compared with 9.4 ± 1.2 g, leptin levels nearly halved from 32.8 ± 7.4 to 16.9 ± 1.9 ng/ml and a 33% reduction of food efficiency. Control MSP showed no effects. Conclusion: Results demonstrate potential of distinct MSPs to improve metabolic risk factors. Further studies investigating mechanism of action and confirming human safety are needed.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2019-0262

Reference49 articles.

1. World Health Organisaton. Global status report on noncommunicable diseases 2014 (2014). www.who.int/nmh/publications/ncd-status-report-2014/en/

2. Economic Costs of Diabetes in the U.S. in 2012

3. The Diabetes Prevention Program (DPP)

4. Current pharmacotherapy for obesity

5. SILICON, FIBRE, AND ATHEROSCLEROSIS

Cited by 13 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Functionalized Periodic Mesoporous Silica Nanoparticles for Inhibiting the Progression of Atherosclerosis by Targeting Low-Density Lipoprotein Cholesterol;Pharmaceutics;2024-01-04

2. Use of Silica Nanoparticles for Drug Delivery in Cardiovascular Disease;Clinical Therapeutics;2023-11

3. Mesoporous Silica Particles Retain Their Structure and Function while Passing through the Gastrointestinal Tracts of Mice and Humans;ACS Applied Materials & Interfaces;2023-02-02

4. New application of a periodic mesoporous nanocrystal silicon–silica composite for hyperlipidemia;Nanoscale Advances;2023

5. The Anti-Obesity Effect of Porous Silica Is Dependent on Pore Nanostructure, Particle Size, and Surface Chemistry in an In Vitro Digestion Model;Pharmaceutics;2022-08-29