Detection of occult hepatitis B virus in patients undergoing chemotherapy in Iran-Reference-Cited by-同舟云学术

Detection of occult hepatitis B virus in patients undergoing chemotherapy in Iran

Published:2022-01 Issue:1 Volume:17 Page:29-36
ISSN:1746-0794
Container-title:Future Virology
language:en
Short-container-title:Future Virology

Author:

Shirmast Paniz¹^ORCID,Shahri Mahdi Abedinzade²^ORCID,Pashangzadeh Salar³⁴^ORCID,Mirshahabi Hessam¹^ORCID,Samadi Elham¹,Motamed Nima⁵

Affiliation:

1. Department of Microbiology & Virology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

2. Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran

3. Iranian Research Center of HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran

4. Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

5. Department of Community Medicine, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

Abstract

Aim: Occult hepatitis B infection (OBI) is life threatening and has a high mortality rate despite applying antiviral treatments in cancer patients. This study aimed to investigate the prevalence of OBI in patients undergoing chemotherapy in Iran. Materials & methods: A total of 342 patients undergoing chemotherapy were enrolled. OBI detection in anti-HBc positive individuals was conducted using nested PCR. Results: Among 342 subjects, 103 (30.1%) were positive for anti-HBc. Fifteen (14.6%) cases of 103 anti-HBc positive samples were also positive for HBsAg. Overall, HBV DNA was positive in three (3.4%) of 88 anti-HBc subjects. Conclusion: Our results indicated that OBI might occur in almost one in 25 anti-HBc-positive patients undergoing chemotherapy.

Funder

Pharmaceutical Biotechnology Research Center, Faculty of Pharmacy, Zanjan University of Medical Sciences, Iran

Publisher

Future Medicine Ltd

Subject

Virology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fvl-2020-0386

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