Practical recommendations for pharmacogenomics-based prescription: 2010 ESF–UB Conference on Pharmacogenetics and Pharmacogenomics

Author:

Becquemont Laurent1,Alfirevic Ana2,Amstutz Ursula3,Brauch Hiltrud4,Jacqz-Aigrain Evelyne5,Laurent-Puig Pierre6,Molina Miguel A7,Niemi Mikko8,Schwab Matthias4,Somogyi Andrew A9,Thervet Eric10,Maitland-van der Zee Anke-Hilse11,van Kuilenburg André BP12,van Schaik Ron HN13,Verstuyft Céline14,Wadelius Mia15,Daly Ann K16

Affiliation:

1. Univ Paris-Sud, Faculty of Medicine Paris-Sud, Pharmacology Department, Assistance Publique Hôpitaux de Paris, Hôpital Bicêtre, Le Kremlin Bicêtre, France.

2. Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK

3. Institute of Clinical Chemistry Inselspital, Bern University Hospital, Bern, Switzerland and Pharmaceutical Outcomes Programme, Child and Family Research Institute, University of British Columbia, Vancouver, Canada

4. Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tuebingen, Tuebingen, Germany

5. Department of Pediatric Pharmacology and Pharmacogenetics, Assistance Publique Hôpitaux de Paris, Hôpital Robert Debré, Paris, France

6. Paris Descartes University, Paris, France and Biochemistry Department, Assistance Publique Hôpitaux de Paris, Hôpital Pompidou, Paris, France

7. Laboratorio de Oncología, Instituto Universitario USP Dexeus, Barcelona, Spain

8. Department of Clinical Pharmacology, University of Helsinki, Helsinki, Finland

9. Faculty of Health Sciences, University of Adelaide, Discipline of Pharmacology, Adelaide, Australia

10. Department of Renal Transplantation, Assistance Publique-Hôpitaux de Paris, Necker-Enfants Malades Hospital, Paris, France, Paris Descartes University, Paris, France

11. Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences (UIPS), University of Utrecht, Utrecht, The Netherlands

12. Academic Medical Center, Laboratory Genetic Metabolic Diseases, Amsterdam, The Netherlands

13. Department of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, The Netherlands

14. Univ Paris-Sud, Faculty of Medicine Paris-Sud, Pharmacology Department, Assistance Publique Hôpitaux de Paris, Hôpital Bicêtre, Le Kremlin Bicêtre, France

15. Department of Medical Sciences, Clinical Pharmacology, Uppsala University, Uppsala, Sweden

16. Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK

Abstract

The present article summarizes the discussions of the 3rd European Science Foundation–University of Barcelona (ESF–UB) Conference in Biomedicine on Pharmacogenetics and Pharmacogenomics, which was held in June 2010 in Spain. It was focused on practical applications in routine medical practice. We provide practical recommendations for ten different clinical situations, that have either been approved or not approved by regulatory agencies. We propose some comments that might accompany the results of these tests, indicating the best drug and doses to be prescribed. The discussed examples include KRAS, cetuximab, panitumumab, EGFR–gefitinib, CYP2D6–tamoxifen, TPMT–azathioprine–6-mercaptopurine, VKORC1/CYP2C9–warfarin, CYP2C19–clopidogrel, HLA-B*5701–abacavir, HLA-B*5701–flucloxacillin, SLCO1B1–statins and CYP3A5–tacrolimus. We hope that these practical recommendations will help physicians, biologists, scientists and other healthcare professionals to prescribe, perform and interpret these genetic tests.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

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