Impact of pain and nonpain co-morbidities on opioid use in women with endometriosis

Author:

Lamvu Georgine12,Soliman Ahmed M3,Johns Beverly3,Vora Jamie B3,Estes Stephanie J4

Affiliation:

1. Orlando Veterans Affairs Medical Center, Orlando, FL, USA

2. University of Central Florida College of Medicine, Orlando, FL, USA

3. AbbVie Inc., North Chicago, IL, USA

4. Penn State Health, Hershey, PA, USA

Abstract

Aim: To evaluate impact of co-morbidities on opioid use in endometriosis. Patients & m ethods: This was a retrospective analysis of data obtained from the Symphony Health database (July 2015–June 2018), which contains medical and pharmacy claims information on 79,947 women with endometriosis. Relative risk (RR) of postdiagnosis opioid use and supply duration associated with baseline co-morbidities were determined. Results: Women with endometriosis using opioids at baseline were 61% more likely to receive opioids postdiagnosis (RR: 1.61; 95% CI: 1.59–1.63). Risk of prolonged opioid supply postdiagnosis was highest for those with prolonged supply at baseline (RR: 21.14; 20.14–22.19), and was 1.32 (1.26–1.38) for patients with ≥1 co-morbidity, 1.37 (1.31–1.43) for pain co-morbidities and 1.07 (1.04–1.11) for psychiatric co-morbidities. Conclusion: Risk of opioid use after endometriosis diagnosis was greater in patients who used opioids before diagnosis. Risk of prolonged opioid use was greater if co-morbidities existed before diagnosis.

Funder

AbbVie

Publisher

Future Medicine Ltd

Subject

Health Policy

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1. Introducing Volume 10 of the Journal of Comparative Effectiveness Research;Journal of Comparative Effectiveness Research;2021-01

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