Epstein–Barr virus and risk of breast cancer: a systematic review and meta-analysis-Reference-Cited by-同舟云学术

Epstein–Barr virus and risk of breast cancer: a systematic review and meta-analysis

Published:2019-08 Issue:24 Volume:15 Page:2873-2885
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Farahmand Mohammad¹,Monavari Seyed Hamidreza²,Shoja Zabihollah³,Ghaffari Hadi²,Tavakoli Mehdi⁴,Tavakoli Ahmad²^ORCID

Affiliation:

1. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

2. Department of Medical Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran

3. Virology Department, Pasteur Institute of Iran, Tehran, Iran

4. Faculty of Electrical & Computer Engineering, Malek-Ashtar University of Technology, Tehran, Iran

Abstract

Despite the numerous publications regarding the role of Epstein–Barr virus (EBV) in breast cancer development, the topic has still remained controversial. The aim of the meta-analysis was to estimate the overall prevalence of EBV in the breast cancer population, and to investigate the association between EBV and breast cancer risk. The overall prevalence of EBV was calculated 26.37% (95% CI: 22–31%) from the 44 included studies. Meta-analysis of 30 case–control studies showed that the pooled association between EBV and risk of breast cancer is odds ratio 4.74 (95% CI: 2.92–7.69; Z = 6.30; p < 0.0001). Our analyses indicate a strong statistical relationship between EBV infection and risk of breast cancer, suggesting a potential role of EBV infection in the development of breast cancer.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon-2019-0232

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