Intensity of chemotherapy for the initial management of newly diagnosed acute myeloid leukemia in older patients

Author:

Michalski Joel M1,Lyden Elizabeth R1,Lee Andrea J1,Al-Kadhimi Zaid S1,Maness Lori J1,Gundabolu Krishna1,Bhatt Vijaya Raj1

Affiliation:

1. Department of Internal Medicine, Section of Hematology and Oncology, University of Nebraska Medical Center, Omaha, NE, USA

Abstract

Aim: This study evaluated the overall survival (OS) of older patients (≥60 years) with acute myeloid leukemia based on the intensity of treatment. Methods: This single center, retrospective study included 211 patients diagnosed between 2000 and 2016, who received 10-day decitabine, low-intensity therapy or high-intensity therapy. Cox regression examined the impact of therapy on OS. Results: Younger patients were more likely to receive high-intensity therapy. Patients who received low-intensity therapy had worse OS compared with high-intensity therapy (median OS: 1.2 vs 8.5 months; p < 0.01). OS was similar with 10-day decitabine (median OS of 6.3 months) compared with either low-intensity therapy or high-intensity therapy. Conclusion: Ten-day decitabine is an effective alternative in older patients with newly diagnosed acute myeloid leukemia.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

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