miRNA changes in the mouse placenta due to bisphenol A exposure-Reference-Cited by-同舟云学术

miRNA changes in the mouse placenta due to bisphenol A exposure

Published:2021-12 Issue:24 Volume:13 Page:1909-1919
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Mao Jiude¹²,Kinkade Jessica A²,Bivens Nathan J³,Rosenfeld Cheryl S²⁴⁵⁶^ORCID

Affiliation:

1. Christopher S Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA

2. Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA

3. Genomics Technology Core Facility, University of Missouri, Columbia, MO 65211, USA

4. MU Institute for Data Science & Informatics, University of Missouri, Columbia, MO 65211, USA

5. Thompson Center for Autism & Neurobehavioral Disorders, University of Missouri, Columbia, MO 65211, USA

6. Genetics Area Program, University of Missouri, Columbia, MO 65211, USA

Abstract

Aim: To determine small RNA expression changes in mouse placenta induced by bisphenol A (BPA) exposure. Methods: Exposing female mice to BPA two weeks prior to conception through gestational day 12.5; whereupon fetal placentas were collected, frozen in liquid nitrogen and stored at -80°C. Small RNAs were isolated and used for small RNA-sequencing. Results: 43 small RNAs were differentially expressed. Target mRNAs were closely aligned to those expressed by thymus and brain, and pathway enrichment analyses indicated that such target mRNAs regulate neurogenesis and associated neurodevelopment processes. Conclusions: BPA induces several small RNAs in mouse placenta that might provide biomarkers for BPA exposure. Further, the placenta might affect fetal brain development through the secretion of miRNAs.

Funder

National Institute of Environmental Health Sciences

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2021-0339

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