The role of matching when adjusting for baseline differences in the outcome variable of comparative effectiveness studies

Author:

Grijalva Carlos G12,Roumie Christianne L23,Murff Harvey J23,Hung Adriana M23,Beck Cole4,Liu Xulei24,Griffin Marie R123,Greevy Robert A24

Affiliation:

1. Department of Health Policy, Vanderbilt University, Nashville, TN, 37232 USA

2. VA Tennessee Valley Geriatric Research Education Clinical Center (GRECC), Nashville, TN, 37212 USA

3. Department of Medicine, Vanderbilt University, Nashville, TN, 37232 USA

4. Department of Biostatistics, Vanderbilt University, Nashville, TN, 37203 USA

Abstract

Aim: Evaluate performance of analytical strategies commonly used to adjust for baseline differences in continuous outcome variables for comparative effectiveness studies. Patients & methods: Data simulations resembling a comparison of HbA1c values after initiation of antidiabetic treatments adjusting for baseline HbA1c. We evaluated change scores, analyses of covariance including linear, nonlinear with/without robust variance estimations, before and after optimal matching. We also evaluated the impact of measurement error. Results: With increasing HbA1c baseline differences between groups, bias in effect estimates and suboptimal CI coverage probabilities increased in all approaches. These issues were further compounded by measurement error. Matching on baseline HbA1c, substantially mitigated these issues. Conclusion: In comparative studies with continuous outcomes, matching on baseline values of the outcome variable improves analytical performance.

Publisher

Future Medicine Ltd

Subject

Health Policy

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3