Biofilm-associated infections: antibiotic resistance and novel therapeutic strategies

Author:

Sun Fengjun12,Qu Feng3,Ling Yan4,Mao Panyong3,Xia Peiyuan1,Chen Huipeng5,Zhou Dongsheng36

Affiliation:

1. Department of Pharmacy, Southwest Hospital, The Third Military Medical University, Chongqing, China

2. State Key Laboratory of Pathogen & Biosecurity, Beijing Institute of Microbiology & Epidemiology, Beijing, China

3. Beijing 302 Hospital, Beijing, China

4. Beijing Institute of Biotechnology, Beijing, China

5. Beijing Institute of Biotechnology, Beijing, China.

6. State Key Laboratory of Pathogen & Biosecurity, Beijing Institute of Microbiology & Epidemiology, Beijing, China. .

Abstract

Infections with bacterial or fungal biofilms have emerged as a major public heath concern because biofilm-growing cells are highly resistant to both antibiotics and host immune defenses. This review focuses on the progress in understanding the mechanisms of biofilm-specific antimicrobial resistance and in developing innovative therapeutic measures based on novel antibiofilm agents.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

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