Plant-derived alkaloids acting on dengue virus and their vectors: from chemistry to pharmacology

Author:

Sarkar Chandan1,Quispe Cristina2,Islam Muhammad T3,Jamaddar Sarmin4,Akram Muhammad5,Munior Naveed6,Martorell Miquel7ORCID,Kumar Manoj8,Sharifi-Rad Javad9ORCID,Cruz-Martins Natália101112ORCID

Affiliation:

1. Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science & Technology University, Gopalganj (Dhaka), 8100, Bangladesh

2. Facultad de Ciencias de la Salud, Universidad Arturo Prat, Iquique, 1110939, Chile

3. Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science & Technology University, Gopalganj (Dhaka), 8100, Bangladesh

4. Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science & Technology University, Gopalganj, 8100, Bangladesh

5. Department of Eastern Medicine, Government College University Faisalabad, Pakistan

6. Department of Biochemistry, Government College University Faisalabad, Pakistan

7. Department of Nutrition & Dietetics, Faculty of Pharmacy, & Centre for Healthy Living, University of Concepción, Concepción, 4070386, Chile

8. Chemical & Biochemical Processing Division, ICAR – Central Institute for Research on Cotton Technology, Mumbai, 400019, India

9. Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador

10. Faculty of Medicine, University of Porto, Alameda Prof. Hernani Monteiro, Porto, 4200-319, Portugal

11. Institute for Research & Innovation in Health (i3S), University of Porto, Porto, 4200-135, Portugal

12. Institute of Research & Advanced Training in Health Sciences & Technologies (CESPU), Rua Central de Gandra, 1317, Gandra PRD, 4585–116, Portugal

Abstract

Dengue is a mosquito-borne viral infection, with its prevention and control depending on effective vector control measures. At present, dengue virus (DENV) is an epidemic in more than 100 countries of Southeast Asia, Africa, Eastern Mediterranean, the Americas and the Western Pacific. Several alkaloids isolated from natural herbs can serve as a reservoir for antiDENV drug development. Traditionally, plant extracts rich in alkaloids are used for the treatment of fever and have also revealed antimicrobial activity against various pathogenic bacteria, fungi and virus. The present narrative review collates the literature-based scenario of alkaloids and derivatives acting on DENV. The mechanism of action of such alkaloids with antiDENV and vector activity is also discussed.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

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