Natural bioactives versus synthetic antibiotics for the attenuation of quorum sensing-regulated virulence factors of <i>Pseudomonas aeruginosa</i>-Reference-Cited by-同舟云学术

Natural bioactives versus synthetic antibiotics for the attenuation of quorum sensing-regulated virulence factors of Pseudomonas aeruginosa

Published:2022-07 Issue:10 Volume:17 Page:773-787
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

Mangal Surabhi¹,Singh Vasundhara²^ORCID,Chhibber Sanjay¹^ORCID,Harjai Kusum¹^ORCID

Affiliation:

1. Department of Microbiology, Panjab University, Chandigarh, 160025, India

2. Department of Applied Sciences, Punjab Engineering College (deemed to be university), Chandigarh, 160012, India

Abstract

Aim: To study the influence of plant volatiles, bioactives and synthetic antibiotics on the attenuation of the quorum sensing (QS)-regulated virulence factors of Pseudomonas aeruginosa. Materials & methods: QS inhibition; the QS-regulated virulence factors pyocyanin, hemolysin, elastase, protease, alginate and pyochelin; and motility phenotypes were performed at sub-MIC to check the attenuation effect of 24 agents on the virulence of P. aeruginosa. Results: Eighteen out of 24 assayed compounds exhibited anti-QS activity and reduced the production of all virulence factors. Cinnamaldehyde, zingerone and lavender oil exhibited a significant reduction in motility phenotypes. Conclusion: Natural phytomolecules as a whole or their bioactives could be used to develop antivirulence drugs after in vivo evaluation.

Funder

DST-SERB

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2021-0199

Reference51 articles.

1. Looming Global-Scale Failures and Missing Institutions

2. Targeting the Pseudomonas quinolone signal quorum sensing system for the discovery of novel anti-infective pathoblockers

3. Azithromycin Inhibits Quorum Sensing in Pseudomonas aeruginosa

4. Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound

5. Down Regulation of Virulence Factors of Pseudomonas aeruginosa by Salicylic Acid Attenuates Its Virulence on Arabidopsis thaliana and Caenorhabditis elegans

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