Tropheryma whipplei intestinal colonization in immunocompromised children in Iran: a preliminary study-Reference-Cited by-同舟云学术

Tropheryma whipplei intestinal colonization in immunocompromised children in Iran: a preliminary study

Published:2021-10 Issue:15 Volume:16 Page:1161-1166
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

Shams Saeed¹,Niloofar Rezaie ²,Beltrame Anna³^ORCID,Moro Lucia³,Piubelli Chiara³,Amiri Fahimeh Bagheri⁴,Esmaeili Saber⁴

Affiliation:

1. Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, 3736175513, Iran

2. Department of Microbiology, Pasteur Institute of Iran, Tehran, 1316943551, Iran

3. Department of Infectious, Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, 37024, Italy

4. Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, 1316943551, Iran

Abstract

Aim & method: Tropheryma whipplei causes Whipple’s disease. Children are reservoirs of this bacterium. The aim of this study was to investigate the presence of T. whipplei in children with immunodeficiency in central Iran from July 2018 to February 2019. Stool samples were tested by SYBR Green and Taq-Man real-time PCR assays. For confirmation, the isolated DNA was sequenced. Results: One hundred and thirty children were enrolled. Acute lymphocytic leukemia was the most reported immunodeficient disease (77%), followed by non-Hodgkin lymphoma and retinoblastoma. Thirteen (10%) children had T. whipplei DNA in the stool; 11.4% of the children under 5 years old were positive. Conclusion: This is the first study showing the circulation of T. whipplei in Iran.

Funder

Pasteur Institute of Iran

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2021-0091

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