Affiliation:
1. Department of Infectious Disease of Wenzhou Central Hospital, Wenzhou Central Hospital,The Dingli Clinical College of Wenzhou Medical University,Wenzhou, 325000, China
Abstract
The study analyzes the risk factors associated with antituberculosis drug-induced liver injury (ATB-DILI), and the relationship between ATB-DILI and NAT2 gene polymorphisms. Out of the 324 included patients, 57 (17.59%) developed ATB-DILI. Age, history of liver disease, alcohol consumption and timing of antituberculosis (ATB) treatment were independent risk factors for ATB-DILI in the patients with tuberculosis (TB; p < 0.05). There was a significant difference in the distribution of NAT2 metabolic phenotypes between the study group and the control group (p < 0.05). The ATB drug treatment for pulmonary TB can cause a high incidence of ATB-DILI. Age, history of liver disease, alcohol consumption and timing of ATB treatment are independent risk factors for ATB-DILI in patients with TB.
Funder
Study on the correlation between N-acetyltransferase 2 gene polymorphism and anti-tuberculosis drug-induced liver injury, Wenzhou Basic Medical Science and Technology Project
Subject
Pharmacology,Genetics,Molecular Medicine