Double adjuvanting strategy for peptide-based vaccines: trimethyl chitosan nanoparticles for lipopeptide delivery-Reference-Cited by-同舟云学术

Double adjuvanting strategy for peptide-based vaccines: trimethyl chitosan nanoparticles for lipopeptide delivery

Published:2016-12 Issue:24 Volume:11 Page:3223-3235
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Marasini Nirmal¹,Giddam Ashwini K¹,Khalil Zeinab G²³,Hussein Waleed M¹,Capon Robert J²,Batzloff Michael R⁴,Good Michael F⁴,Toth Istvan¹²⁵,Skwarczynski Mariusz¹

Affiliation:

1. School of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, Australia

2. Institute for Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, Australia

3. Diamantina Institute, The University of Queensland, Woolloongabba, QLD, 4102, Australia

4. Institute for Glycomics, Griffith University, Gold Coast, QLD 4222, Australia

5. School of Pharmacy, The University of Queensland, Woolloongabba, QLD 4102, Australia

Abstract

Aim: To develop novel polymer-based nanoscale delivery system for lipopeptide-based vaccine against group A Streptococcus (GAS). Materials & methods: Four types of lipopeptide antigen-loaded polymeric nanoparticles (NP) were prepared. NP were accessed for their capacity to be taken up by dendritic cells; effect on dendritic cell maturation; ability to induce mucosal and systemic immunity; and capability to induce antibody responses that opsonize GAS bacteria. Results & discussion: The combination of adjuvanting properties of lipopeptides and dextran/trimethyl chitosan-based NP had a synergistic effect on humoral immunity, and the produced antibodies showed high opsonic activity against clinical GAS isolates. Conclusion: Biocompatible NP-bearing trimethyl chitosan and dextran are efficient as mucosal adjuvants for the intranasal delivery of lipopeptide-based vaccines.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2016-0291

Reference42 articles.

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