Ligand-mediated nanomedicines against breast cancer: a review

Author:

Picheth Guilherme F12ORCID,Ganzella Fernando A de O1,Filizzola João OC1,Canquerino Yan K1,Cardoso Gabriela C1,Collini Michelle B1,Colauto Leonardo B1,Figueroa-Magalhães Maria Cristina2,Cavalieri Edneia ASR1,Klassen Giseli1

Affiliation:

1. Department of Basic Pathology, Federal University of Paraná, Curitiba, Paraná, Brazil

2. School of Medicine, Pontifical Catholic University of Paraná, Curitiba, Paraná, Brazil

Abstract

Ligand-mediated targeting represents the cutting edge in precision-guided therapy for several diseases. Surface engineering of nanomedicines with ligands exhibiting selective or tailored affinity for overexpressed biomolecules of a specific disease may increase therapeutic efficiency and reduce side effects and recurrence. This review focuses on newly developed approaches and strategies to improve treatment and overcome the mechanisms associated with breast cancer resistance.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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