Carbapenemase-producing <i>Klebsiella pneumoniae</i> in community settings: a cross-sectional study in Belgrade, Serbia-Reference-Cited by-同舟云学术

Carbapenemase-producing Klebsiella pneumoniae in community settings: a cross-sectional study in Belgrade, Serbia

Published:2023-05 Issue:7 Volume:18 Page:389-397
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

Brkić Snežana¹^ORCID,Božić Dragana D²^ORCID,Stojanović Nena³,Bulbuk Dragana¹,Mihajlo Jovanović ¹,Ćirković Ivana⁴^ORCID

Affiliation:

1. Institute for Laboratory Diagnostics ‘Konzilijum’, Belgrade, 11000, Serbia

2. Department of Microbiology & Immunology, Faculty of Pharmacy, University of Belgrade, Belgrade, 11000, Serbia

3. City Institute of Public Health of Belgrade, Belgrade, 11000, Serbia

4. Institute of Microbiology & Immunology, Faculty of Medicine, University of Belgrade, Belgrade, 11000, Serbia

Abstract

Aim: The types of carbapenemases and clonal relatedness among community isolates of carbapenemase-producing Klebsiella pneumoniae in Belgrade, Serbia, were determined. Materials & methods: During the period 2016–2020, K. pneumoniae community isolates were screened for carbapenemases, and carbapenemase production was confirmed by multiplex PCR. Clonality was determined based on genetic profiles obtained by enterobacterial repetitive intergenic consensus PCR. Results: Carbapenemase genes were detected in 114 of 4800 isolates (2.4%). The most frequent gene was blaOXA-48-like. Most isolates (70.5%) were grouped in ten clusters. Cluster 11 contained 16.4% of all blaOXA-48-like-positive isolates, and all blaKPC-positive isolates were grouped in one cluster. Conclusion: Laboratory-based detection and surveillance are highly recommended in order to control the spread of resistance in community settings.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2022-0201

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