Human RSVA-ON1, the only genotype present during 2019–2020 winter season in Riyadh, Saudi Arabia: a retrospective study-Reference-Cited by-同舟云学术

Human RSVA-ON1, the only genotype present during 2019–2020 winter season in Riyadh, Saudi Arabia: a retrospective study

Published:2023-11 Issue:16 Volume:18 Page:1043-1055
ISSN:1746-0794
Container-title:Future Virology
language:en
Short-container-title:Future Virology

Author:

Ahmed Anwar¹^ORCID,Alhetheel Abdulkarim²,Parveen Shama³,Almajhdi Fahad N⁴,Alkubaisi Noorah A⁴,Al-Saadi Muslim Mohammed⁵

Affiliation:

1. Centre of Excellence in Biotechnology Research, College of Applied Medical Science, King Saud University, Riyadh, Saudi Arabia

2. Department of Pathology & Laboratory Medicine, College of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia

3. Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India

4. Department of Botany & Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia

5. Department of Pediatrics, College of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia

Abstract

Aim: The study aimed to analyze human respiratory syncytial virus (hRSV) strains in nasopharyngeal aspirates obtained retrospectively. Materials & methods: Clinical information of ARI patients (n = 53) was accessed and 2nd hypervariable region of G protein gene of RSV was sequenced and analyzed. Results: Cough (98.1%), fever 40 (75.4%) and shortness of breath 32 (60.3%) were the common symptom. Sequence determination (n = 45) categorized all the strains in ON1 genotype. Potential O- and N- glycosylation were observed at some sites and purifying selections were observed at 274 and 320 codon positions. Conclusion: The study reports replacement of other RSVA genotypes with ON1. The future course of studies should emphasize on clinical implications of presence of hRSVA-ON1 genotype in a given population.

Funder

King Abdulaziz City for Science and Technology

Publisher

Informa UK Limited

Subject

Virology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fvl-2023-0173

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