Regulation of stem cell fate by nanomaterial substrates

Author:

Mashinchian Omid1,Turner Lesley-Anne2,Dalby Matthew J2,Laurent Sophie34,Shokrgozar Mohammad Ali5,Bonakdar Shahin5,Imani Mohammad6,Mahmoudi Morteza789

Affiliation:

1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences, PO Box 14177–55469, Tehran, Iran

2. Centre for Cell Engineering, Joseph Black Building, Institute of Biomedical & Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, UK

3. Department of General, Organic & Biomedical Chemistry, NMR & Molecular Imaging Laboratory, University of Mons, Avenue Maistriau 19, B-7000 Mons, Belgium

4. CMMI – Center for Microscopy & Molecular Imaging, Rue Adrienne Bolland, 8, B-6041 Gosselies, Belgium

5. National Cell Bank, Pasteur Institute of Iran, PO Box 13169–43551, Tehran, Iran

6. Novel Drug Delivery Systems Department, Iran Polymer & Petrochemical Institute (IPPI), PO Box 14965/115, Tehran, Iran

7. Department of Nanotechnology & Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, PO Box 14155–6451, Tehran, Iran

8. Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305–5101, USA

9. Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305–5101, USA

Abstract

Stem cells are increasingly studied because of their potential to underpin a range of novel therapies, including regenerative strategies, cell type-specific therapy and tissue repair, among others. Bionanomaterials can mimic the stem cell environment and modulate stem cell differentiation and proliferation. New advances in these fields are presented in this review. This work highlights the importance of topography and elasticity of the nano-/micro-environment, or niche, for the initiation and induction of stem cell differentiation and proliferation.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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