Radiation recall dermatitis after treatment of stage IV breast cancer with nivolumab: a case report

Author:

Billena Cole1,Padia Shilpa1,O’Brien Bridget1,Knoble Jeanna2,Gokhale Abhay3,Rajagopalan Malolan3

Affiliation:

1. Department of Surgery, Mount Carmel Health System, Columbus, OH 43081, USA

2. Department of Hematology, Oncology Zangmeister Cancer Center, Columbus, OH 43219, USA

3. Department of Radiation Oncology, Mount Carmel Health System, Columbus, OH 43081, USA

Abstract

Radiation recall dermatitis (RRD) is an uncommon dermatologic reaction provoked notably by chemotherapy in an area of skin irradiated weeks to years prior. We report a case of RRD with nivolumab in a woman with breast cancer. The patient was diagnosed with invasive ductal carcinoma of the left breast with an isolated spinal metastasis approached in an oligometastatic fashion with neoadjuvant chemotherapy, modified radical mastectomy and adjuvant radiotherapy. Unfortunately, after progression of bony metastases treated with radiotherapy, the patient received nivolumab and subsequently developed a rash corresponding to the adjuvant radiation field. This case highlights the unpredictable nature and characteristic rash of RRD. It is an important differential diagnosis for multidisciplinary teams who also see chemotherapy-induced dermatitis and immune-related adverse events.

Publisher

Future Medicine Ltd

Subject

Oncology,Immunology,Immunology and Allergy

Reference51 articles.

1. Noone AM, Howlader N, Krapcho M SEER Cancer Statistics Review, 1975–2015. National Cancer Institute. Bethesda, MD, USA https://seer.cancer.gov/csr/1975_2015/ based on November 2017 SEER data submission, posted to the SEER website April 2018.

2. Changing Treatment Paradigms in Metastatic Breast Cancer

3. Immunotherapy in Breast Cancer: the New Frontier

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