Cell-based cardiac pumps and tissue-engineered ventricles

Abstract

Mortalities resulting from cardiovascular disorders remain high, with an urgent need to develop novel treatment modalities. Tissue-engineering therapies aim to provide cell-based alternatives to conventional options. Significant technological advancements have occurred during the last decade towards the fabrication of functional 3D heart muscle in vitro. More recent research has focused on the development of cell-based cardiac pumps and tissue-engineered ventricles. The global objective of this collective work is to simulate the functional performance of the left ventricle, utilizing completely cell-based options. Current prototypes have shown several physiological performance metrics, including the ability of these devices to generate intraluminal pressure upon electrical stimulation. This review will highlight the transition from tissue engineering 3D heart muscle to cell-based cardiac pumps/ventricles.