Urotensin II receptor on preoperative biopsy is associated with upstaging and upgrading in prostate cancer-Reference-Cited by-同舟云学术

Urotensin II receptor on preoperative biopsy is associated with upstaging and upgrading in prostate cancer

Published:2015-11 Issue:22 Volume:11 Page:3091-3098
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

De Cobelli Ottavio¹²,Buonerba Carlo³,Terracciano Daniela⁴,Bottero Danilo¹,Lucarelli Giuseppe⁵,Bove Pierluigi⁶,Altieri Vincenzo⁷,Coman Ioman²,Perdonà Sisto⁸,Facchini Gaetano⁹,Berretta Massimiliano¹⁰,Di Lorenzo Giuseppe³,Grieco Paolo¹¹,Novellino Ettore¹¹,Franco Renato¹²,Caraglia Michele¹³,Manini Claudia¹⁴,Mirone Vincenzo¹⁵,De Placido Sabino³,Sonpavde Guru¹⁶,Ferro Matteo¹

Affiliation:

1. Division of Urology, European Institute of Oncology, Milan, Italy

2. Department of Urology, ‘Iuliu Hatieganu’ University of Medicine & Pharmacy, Cluj-Napoca, Romania

3. Oncologia Urologica, Dipartimento di Medicina Clinica e Chirurgia, Azienda Ospedaliera Universitaria ‘Federico II’, Napoli, Italy

4. Department of Translational Medical Sciences, University ‘Federico II’, Naples, Italy

5. Department of Emergency & Organ Transplantation – Urology, Andrology & Kidney Transplantation Unit, University of Bari, Bari, Italy

6. Department of Urology, Tor Vergata University of Rome, V.le Oxford 81, Rome, 00133, Italy

7. Department of Urology of San Giovanni di Dio & Ruggi d'Aragona Hospital, University of Salerno, Salerno, SA, Italy

8. Department of Urology, National Cancer Institute of Naples, Naples, Italy

9. Gineco-urological Department, National Cancer Institute of Naples ‘Fondazione G Pascale’, Naples, Italy

10. Department of Medical Oncology, National Cancer Institute, Aviano, Italy

11. Department of Pharmacy, University of Naples, Federico II, Naples 80131, Italy

12. Pathology Unit, National Cancer Institute ‘Fondazione G. Pascale’, Naples, Italy

13. Department of Biochemistry, Biophysics & General Pathology, Second University of Naples, Naples, Italy

14. Division of Pathology, Giovanni Bosco Hospital, Turin, Italy

15. Urology Division, University Federico II of Naples, Napoli, Italy

16. UAB (University of Alabama at Birmingham) Cancer Center, Birmingham, AL 35233, USA

Abstract

Aim: A higher Gleason score was associated with a lower tumor urotensin II receptor (UTII-R) expression in prostate cancer patients. Methods: A retrospective review of formalin-fixed paraffin-embedded tumor tissue derived from those who had prostatectomy and matching biopsy specimens was conducted at six Institutions. UTII-R expression was evaluated on biopsy by immunohistochemistry. Results: A total of 58 subjects undergoing radical prostatectomy were included. At multivariate analysis, low UTII-R expression was a significant predictor of Gleason upgrading, with an odds ratio of 10.3 (95% CI: 1.55–68.4), and of pathology upstaging, with an odds ratio of 11.1 (95% CI: 1.23–100.48). Conclusions: UTII-R expression on biopsy was associated with Gleason upgrading and pathology upstaging in prostate cancer patients.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon.15.249

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