Affiliation:
1. Orenburg State Medical University; Orenburg Regional Clinical Oncology Dispensary
2. P.A.Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre
Abstract
Purpose of the study.To give a qualitative and quantitative assessment of different types of tumor microvessels depending on the histological type of cervical cancer (CC).Material and methods.The tumor samples from 76 patients with CC stage I–IIA who received the surgical treatment on the first phase were the object of study. The immunohistochemical study was performed using antibodies to CD34 and podoplanin. Statistical analysis of the data was performed using the Statistica 6.0 software.Results.In CC, the following types of tumor microvessels have been identified: normal microvessels, dilated capillaries (DCs) with a normal endothelial lining, DCs with a weak expression of CD34, DCs of contact type, capillaries in the solid component of tumor, the atypical dilated capillaries (ADCs), the structures with partial endothelial lining and the lymphatic capillaries in lymphoid and polymorphic cell infiltrates. It was found that DCs with a mild expression of CD34 (p=0.0005), DCs of contact type (p=0.000005), and capillaries in the solid component of tumor (p=0.006) were correlated with the prognosis in early CC. The detection frequency of this tumor microvessels was lower in more prognostically favorable squamous non-keratinizing CC, while in the prognostically unfavorable squamous cell keratinizing CC and adenocarcinoma of the cervix uteri, the higher DCs values with a mild expression of CD34 (р=0,004 and р=0.005, respectively) and DC of contact type (p=0.02 and p=0.14, respectively) were typical.Conclusion.We consider it is expedient to further study the relationship of different types of tumor microvessels with clinical and morphological characteristics and prognosis of cervical cancer.
Subject
Microbiology (medical),Immunology,Immunology and Allergy
Reference28 articles.
1. Arbyn M., Weiderpass E., Bruni L., de Sanjosé S., Saraiya M., Ferlay J. et al. Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis. Lancet Glob Health. 2020 Feb;8(2):e191-e203. https://doi.org/10.1016/S2214-109X(19)30482-6.
2. Sostoyanie onkologicheskoj pomoshchi naseleniyuRossii v 2018 godu. [The status of cancer care for the population of Russia in 2018]. Ed by Kaprin A.D., Starinskiy V.V., Petrovа G.V. Moscow: MNII them. P.A. Herzen branch of the FSBI "NIIRTS" Ministry of Health of Russia. 2019. p.236. ISBN 978-5-85502-250-6(In Russian).
3. Zhurman VN, Eliseevа EV, Gulevich AP, Slobodenyuk EV. Socio-economic effects of women mortality from female genitals malignant tumors. Far East Medical Journal. 2016(1):89-91. (In Russian).
4. Gatagazheva ZМ, Dikke GB, Uzdenova ZKh, Tsallagova LV, Zelenova ОV, Мisirova ММ. Organizational and economic aspects of optimization of a cervical cancer screening programme in the Republic of Ingushetia. Gynecology, Obstetricsand Perinatology. 2020;19(1):151–157. (In Russian). https://doi.org/10.20953/1726-1678-2020-1-151-157
5. Kubota S, Kobayashi E, Kakuda M, Matsuzaki S, Ueda Y, Yoshino K, et al. Retrospective analysis for predictors of parametrial involvement in IB cervical cancer. J Obstet Gynaecol Res. 2019 Mar;45(3):679–685. https://doi.org/10.1111/jog.13855
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献