Screening clinical signs of TB in HIV-infected convicts in correctional facilities federal penitentiary servicе

Abstract

Aim. To identify the main clinical signs that make it possible to further detect the development of tuberculosis in patients with HIV infection in a correctional facility of the Federal Penitentiary Service with a high degree of probability.Materials and methods: 569 patients with tuberculosis, 363 with HIV infection, and 206 prisoners without HIV infection. Age: from 18 to 62 years old.Results. In this study, we have identified highly probable clinical symptoms in HIV-infected prisoners in the presence of tuberculosis and weakness, cough, clinical manifestations of mycosis, hepatomegaly and lymphadenopathy. The sensitivity of detecting tuberculosis in patients with HIV infection for complaints of weakness — 61,2%, specificity — 57,3%, cough with sputum — 67,8 and 51,0%, clinical manifestation of mycosis — 95,6 and 80,6%, hepatomegaly — 48,8 and 100%, lymphadenopathy — 50,4 and 100,0%, respectively. The combined combination of these clinical manifestations gives a sensitivity of 94,6% with 81,9% specificity. The percentage of correctly classified cases according to this model is 88,93%, with the area under the ROC curve (AUC) — 0,963.