On the question of studying hyperoxic sanogenesis SARS-CoV-2-associated pneumonia

Abstract

The article is devoted to the analysis of literature data on the use of hyperbaric oxygenation (HBO) in patients with COVID-19, complicated by the development of SARS-CoV-2-associated pneumonia to build a hypothesis about possible mechanisms of therapeutic action of hyperbaric oxygen (HBO2) in this pathology. The expediency of using «soft» (1.3–2.0 attacks, 40–60 min) HBO modes in SARS-CoV-2-associated pneumonia is substantiated. Several possible mechanisms of elimination of HBO2 violation of lung gas exchange function in SARS-CoV-2-associated pneumonia are considered. Firstly, hyperoxic stimulation of diaphragm contraction. Secondly, the inhibitory effect of HBO2 on the development of interstitial and alveolar edema in the lungs. Thirdly, elimination of HBO2 stimulating effect of thrombin and fibrinogen on contractility of pulmonary capillary endotheliocytes. Fourth, regulation of HBO2 metabolism of fibronectin, thromboplastin, von Willibrant factors, and platelet activation factor in the wall of pulmonary capillaries. As a result, its thrombogenic activity increases in this pathology.