Affiliation:
1. UFF; UNIRIO; UFRJ; FIOCRUZ, Brazil
Abstract
The authors present a study of five cases of vulvar congenital papillomas and papillomatoses in stillborns and neonates dead upon birth. The studied material was collected from five necropsies. The histopathological evaluation showed hyperkeratosis, acanthosis, papillomatosis, perinuclear haloes, and nuclear abnormalities. In three of the cases, the electron microscopy identified nuclear and cytoplasmatic viral particles ranging from 40 to 60 nm in size, compatible with HPV. The immunohistochemical study of those lesions showed nuclear and cytoplasmatic positivity. The authors concluded that the presence of viral particles suggestive of HPV added to the immunopositivity indicated the possibility of viral infection.
Reference63 articles.
1. The human papillomaviruses: Bull;ORTH G.;Cancer,1978
2. The molecular biology of Human papillomaviroses and the pathogenesis of genital papillomas and neoplasma;OSTROW R.S.;Cancer and Metastasis Review,1987
3. Epidemiology of Human papillomavirus (HPV) infection and their associations with genital squamous cell cancer;SYRJANEN K.J.;APMIS,1989
4. Papillomavirus humano: aspectos biológicos, clínicos e morfológicos;DIAS E.P.;JMB,1993
5. Condyloma acuminata in children;DE JONG A.R.;Am. J. Dis. Child.,1982
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Perinatal Infections;Diagnostic Pathology of Infectious Disease;2018
2. Condyloma acuminatum: its histopathological pattern;Sao Paulo Medical Journal;1997-04