Affiliation:
1. University of São Paulo
Abstract
BACKGROUND: The development of human esophageal cancer is a multistep, progressive process. An early indicator of this process is an increased proliferation of esophageal epithelial cells morphologically including basal cell hyperplasia, dysplasia, carcinoma in situ and advanced esophageal squamous cell carcinoma. The process of tumorigenesis at cellular level is related to disorders of the control of cell proliferation and differentiation and controlled cell death (apoptosis). Most of cancer cells contain genetic alterations related to the control of these processes, including transcription factors and apoptosis related proteins. AIM: In this review, the current knowledge of the genetic profile of this subtype of esophageal tumor is discussed, focusing on the potential of the development of novel tools for clinical management of esophageal squamous cell carcinoma. CONCLUSIONS: The advances in the field of molecular biology have let us to deeper our knowledge of the process of carcinogenesis of esophagus. Ideally, this knowledge should be translated in benefits for patients suffering from cancer. Thus, better understanding of molecular alterations during carcinogenesis is expected to improve tumor control and prevention and also may lead to better disease management.
Reference44 articles.
1. Insufficient effect of p27(KIP1) to inhibit cyclin D1 in human esophageal cancer in vitro;Anayama T;Int J Oncol,2001
2. Novel polymorphism in p21(waf1/cip1) cyclin dependent kinase inhibitor gene: association with human esophageal cancer;Bahl R;Oncogene,2000
3. Requirement for p53 and p21 to sustain G2 arrest after DNA damage;Bunz F;Science,2000
4. TP53 tumor suppressor gene: a model for investigating human mutagenesis;Caron de Fromental C;Genes Chromosomes Cancer,1992
5. Accumulation of p53 in esophageal squamous cell carcinoma;Chino O;Int J Mol Med,2001
Cited by
49 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献