Total agenesis of the corpus callosum in a patient with childhood-onset schizophrenia

Author:

Hallak Jaime Eduardo Cecilio1,Crippa José Alexandre de Sousa1,Pinto Joel Porfírio1,Sousa João Paulo Machado de1,Trzesniak Clarissa1,Dursun Serdar Murat2,McGuire Phillip3,Deakin John Francis William2,Zuardi Antonio Waldo1

Affiliation:

1. University of São Paulo, Brazil

2. University of Manchester, UK

3. Institute of Psychiatry, UK

Abstract

The hypothesis that schizophrenia involves aberrant inter-hemispheric communication has a long pedigree, however its precise role remains unclear. We therefore report the case of a total agenesis of the corpus callosum in a 21-year-old man with childhood-onset schizophrenia. The presence of schizophrenia with very early onset on absence of corpus callosum offers an opportunity to examine neurodevelopmental model and theories regarding to interhemispheric communication in the pathogenesis of psychosis.

Publisher

FapUNIFESP (SciELO)

Subject

Neurology,Clinical Neurology

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