Affiliation:
1. University of Oeste Paulista, Brazil
2. University of Serra dos Órgãos, Brazil
3. University of Oeste Paulista
Abstract
Dermatitis herpetiformis (DH) or Duhring-Brocq disease is a chronic bullous disease characterized by intense itching and burning sensation in the erythematous papules and urticarial plaques, grouped vesicles with centrifuge growth, and tense blisters. There is an association with the genotypes HLA DR3, HLA DQw2, found in 80-90% of cases. It is an IgA-mediated cutaneous disease, with immunoglobulin A deposits appearing in a granular pattern at the top of the dermal papilla in the sublamina densa area of the basement membrane, which is present both in affected skin and healthy skin. The same protein IgA1 with J chain is found in the small intestinal mucosa in patients with adult celiac disease, suggesting a strong association with DH. Specific antibodies such as antiendomysium, antireticulina, antigliadin and, recently identified, the epidermal and tissue transglutaminase subtypes, as well as increased zonulin production, are common to both conditions, along with gluten-sensitive enteropathy and DH. Autoimmune diseases present higher levels of prevalence, such as thyroid (5-11%), pernicious anemia (1-3%), type 1 diabetes (1-2%) and collagen tissue disease. The chosen treatment is dapsone and a gluten-free diet.
Reference44 articles.
1. Lever's Histopathology of the Skin;Cohen LM,1997
2. Dermatology in General Medicine;Katz SI,2010
3. Dermatologia;Azulay-Abulafia L,2006
4. The desmosome: cell science lessons from human diseases;Kottke MD;J Cell Sci,2006
5. Epidermal basement membrane: its molecular organization and blistering disorders;Masunaga R;Connect Tissue Res,2006
Cited by
51 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. A comprehensive review of biochemical, functional, and dietary implications of Gluten;Annals of Phytomedicine An International Journal;2024-07
2. Dermatitis herpetiformis;Pediatric and Adult Celiac Disease;2024
3. Autoimmune Bullous Dermatoses;Dermatology in Public Health Environments;2023
4. Blasenbildende Autoimmundermatosen;Therapie-Handbuch - Dermatologie und Allergologie;2023
5. Humoral epitope spreading in autoimmune bullous diseases: An update;Translational Autoimmunity;2023