Assessment of the toxicogenic effects and cell death potential of the ester (Z)-methyl 4-((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)amino)-4-oxobut-2-anoate in combination with cisplatin, cyclophosphamide and doxorubicin

Author:

Juliano Oliveira Rodrigo1ORCID,Pereira Fabrícia Paniago Ajala Nery2,Silveira Ingridhy Ostaciana Maia Freitas da3,Lima Ricardo Vieira de4,Berno Claudia Rodrigues2,Pesarini João Renato5,Antoniolli-Silva Andréia Conceição Milan Brochado2,Monreal Antônio Carlos Duenhas3,Adilson Beatriz6,Lima Dênis Pires de6,Gomes Roberto da Silva7ORCID

Affiliation:

1. Hospital Universitário “Maria Aparecida Pedrossian”, Brazil; Universidade Federal de Mato Grosso do Sul, Brazil; Universidade Federal de Mato Grosso do Sul, Brazil; Universidade Estadual de Londrina, Brazil

2. Hospital Universitário “Maria Aparecida Pedrossian”, Brazil; Universidade Federal de Mato Grosso do Sul, Brazil

3. Universidade Federal de Mato Grosso do Sul, Brazil

4. Universidade Federal de Mato Grosso do Sul, Brazil; Universidade Federal da Grande Dourados, Brazil

5. Hospital Universitário “Maria Aparecida Pedrossian”, Brazil; Universidade Federal de Mato Grosso do Sul, Brazil; Universidade Católica Dom Bosco, Brazil

6. Universidade Federal de Mato Grosso do Sul, Brazil; Universidade Federal de Mato Grosso do Sul, Brazil

7. Universidade Federal de Mato Grosso do Sul, Brazil; Universidade Federal da Grande Dourados, Brazil; Harvard University, USA

Publisher

FapUNIFESP (SciELO)

Subject

Genetics,Molecular Biology

Reference39 articles.

1. Cancer and cell cycle-specific and cell cycle nonspecific anticancer DNA-interactive agents: An introduction;Almeida VL;Quím Nova,2005

2. Design and synthesis of some new thiophene, thienopyrimidine and thienothiadiazine derivatives of antipyrine as potential antimicrobial agents;Aly HM;Eur J Med Chem,2011

3. The antioxidant and antigenotoxic properties of citrus phenolics limonene and naringin;Bacanli M;Food Chem Toxicol,2015

4. 4-Aminoantipyrine reduces toxic and genotoxic effects of doxorubicin, cisplatin, and cyclophosphamide in male mice;Berno CR;Mutat Res Genet Toxicol Environ Mutagen,2016

5. The role of apoptosis in cancer development and treatment response;Brown JM;Nat Rev Cancer,2005

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