Enamel hypoplasia in a litter of rats with alloxan-induced diabetes mellitus

Author:

Silva-Sousa Yara Teresinha Corrêa1,Peres Luiz Cesar2,Foss Milton Cesar3

Affiliation:

1. UNAERP, Brazil

2. University of São Paulo

3. University of São Paulo, Ribeirão Preto, Brazil

Abstract

Enamel hypoplasia is an important clinical problem commonly seen in children born to diabetic women. We aimed to characterize the enamel hypoplasia in Wistar rats born to alloxan-induced diabetes mellitus rats. Groups consisted of pregnant rats supplemented (ISDR) or not (NISDR) with insulin and controls, in which sterile saline solution was administered instead of alloxan or insulin. The mandibular incisors of one-month-old rats born to these mothers were analyzed. Whitish defective enamel was found macroscopically in both experimental groups (ISDR = 37.5%, NISDR = 33.3%) but not in the control group. Mild to severe enamel hypoplasia was observed by scanning electron microscopy (ISDR = 93.8%; NISDR = 100%, control = 4.2%). The severity of hypoplasia correlated positively with the maternal level of blood glucose. In conclusion, the intensity of enamel hypoplasia in the teeth of the litter born to alloxan-induced diabetic rats was variable and was dependent on the glycemic level of the pregnant rat.

Publisher

FapUNIFESP (SciELO)

Subject

General Dentistry

Reference20 articles.

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2. Neonatal deaths among infants of diabetic mothers;Driscoll SG;Amer J Dis Child,1961

3. Experimental diabetes in pregnant mice: Prevention of congenital malformations in offspring by insulin;Horii KI;Diabetes,1966

4. A new model for study of mild diabetes during pregnancy: Syngeneic islet-trans planted STZ-induced diabetic rats;Ryan EA;Diabetes,1993

5. Influences of age and duration of diabetes on dental development in children;Adler P;J Dent Res,1973

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