Effect of vaporized perfluorocarbon on oxidative stress during the cold ischemia phase of lung graft preservation-Reference-Cited by-同舟云学术

Effect of vaporized perfluorocarbon on oxidative stress during the cold ischemia phase of lung graft preservation

Published:2019 Issue:4 Volume:45 Page:
ISSN:1806-3756
Container-title:Jornal Brasileiro de Pneumologia
language:
Short-container-title:J. bras. pneumol.

Author:

Ferrari Renata Salatti¹^ORCID,Thomaz Leonardo Dalla Giacomassa Rocha²^ORCID,Simoneti Lucas Elias Lise²^ORCID,Ulbrich Jane Maria³^ORCID,Andrade Cristiano Feijó³^ORCID

Affiliation:

1. Universidade Federal do Rio Grande do Sul, Brazil

2. Hospital de Clínicas de Porto Alegre, Brasil

3. Universidade Federal do Rio Grande do Sul, Brazil; Hospital de Clínicas de Porto Alegre, Brasil

Abstract

ABSTRACT Liquid perfluorocarbon (PFC) instillation has been studied experimentally as an adjuvant therapy in the preservation of lung grafts during cold ischemia. The objective of this study was to evaluate whether vaporized PFC is also protective of lung grafts at different cold ischemia times. We performed histological analysis of and measured oxidative stress in the lungs of animals that received only preservation solution with low-potassium dextran (LPD) or vaporized PFC together with LPD. We conclude that vaporized PFC reduces the production of free radicals and the number of pulmonary structural changes resulting from cold ischemia.

Publisher

FapUNIFESP (SciELO)

Subject

Pulmonary and Respiratory Medicine

Link

http://www.scielo.br/pdf/jbpneu/v45n4/1806-3713-jbpneu-45-04-e20170288.pdf

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