Serological evidence of Rickettsia parkeri as the etiological agent of rickettsiosis in Uruguay

Author:

Conti-Díaz Ismael A.1,Moraes-Filho Jonas2,Pacheco Richard C.2,Labruna Marcelo B.2

Affiliation:

1. National University, Uruguay

2. University of São Paulo, Brazil

Abstract

We report three new rickettsiosis human cases in Uruguay. The three clinical cases presented clinical manifestations similar to previous reported cases of Rickettsia parkeri in the United States; that is mild fever (< 40 ºC), malaise, headache, rash, inoculation eschar at the tick bite site, regional lymphadenopathy, and no lethality. Serological antibody-absorption tests with purified antigens of R. parkeri and Rickettsia rickettsii, associated with immunofluorescence assay indicated that the patients in two cases were infected by R. parkeri. Epidemiological and clinical evidences, coupled with our serological analysis, suggest that R. parkeri is the etiological agent of human cases of spotted fever in Uruguay, a disease that has been recognized in that country as cutaneous-ganglionar rickettsiosis.

Publisher

FapUNIFESP (SciELO)

Subject

Infectious Diseases,General Medicine

Reference18 articles.

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2. Diagnosis and management of tickborne rickettsial diseases: Rocky Mountain spotted fever, ehrlichioses, and anaplasmosis -- United States: a practical guide for physicians and other health-care and public health professionals;CHAPMAN A.S;MMWR Recomm. Rep.,2006

3. Rickettsiosis por Rickettsia conorii (fiebre botonosa del Mediterráneo o fiebre de Marsella): Estado actual en el Uruguay;CONTI DÍAZ I.A;Rev. Med. Uruguay,2001

4. Rickettsiosis caused by Rickettsia conorii in Uruguay;CONTI DÍAZ I.A;Ann. N. Y. Acad. Sci.,2003

5. Rickettsiosis cutáneo-ganglionar por Rickettsia conorii en el Uruguay;CONTI DÍAZ I.A;Rev. Inst. Med. trop. S. Paulo,1990

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