Pseudomonas aeruginosa infection in patients with cystic fibrosis: scientific evidence regarding clinical impact, diagnosis, and treatment

Author:

Silva Filho Luiz Vicente Ribeiro Ferreira da1,Ferreira Flavia de Aguiar2,Reis Francisco Jose Caldeira3,Britto Murilo Carlos Amorim de4,Levy Carlos Emilio5,Clark Otavio6,Ribeiro Jose Dirceu5

Affiliation:

1. Universidade de Sao Paulo, Brasil

2. Novartis Brasil, Brasil

3. Grupo Brasileiro de Estudos em Fibrose Cistica, Brasil

4. Instituto Materno Infantil de Pernambuco, Brasil

5. Universidade Estadual de Campinas, Brasil

6. Evidencias Consultoria, Brasil

Abstract

Evidence-based techniques have been increasingly used in the creation of clinical guidelines and the development of recommendations for medical practice. The use of levels of evidence allows the reader to identify the quality of scientific information that supports the recommendations made by experts. The objective of this review was to address current concepts related to the clinical impact, diagnosis, and treatment of Pseudomonas aeruginosa infections in patients with cystic fibrosis. For the preparation of this review, the authors defined a group of questions that would be answered in accordance with the principles of PICO–an acronym based on questions regarding the Patients of interest, Intervention being studied, Comparison of the intervention, and Outcome of interest. For each question, a structured review of the literature was performed using the Medline database in order to identify the studies with the methodological design most appropriate to answering the question. The questions were designed so that each of the authors could write a response. A first draft was prepared and discussed by the group. Recommendations were then made on the basis of the level of scientific evidence, in accordance with the classification system devised by the Oxford Centre for Evidence-Based Medicine, as well as the level of agreement among the members of the group.

Publisher

FapUNIFESP (SciELO)

Subject

Pulmonary and Respiratory Medicine

Reference104 articles.

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4. Genetics of cystic fibrosis;Lommatzsch ST;Semin Respir Crit Care Med,2009

5. Diagnosing and managing infection in CF;Ratjen F;Paediatr Respir Rev,2006

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