Caryocar villosum attenuates inflammation by inhibiting CXCL1 activation and peripheral hyperalgesia through opioid pathway modulation

Author:

SOARES Gutemberg Lopes1,HILGENBERG Lívia Christine Ribeiro1,BATISTA Giovana Reis1,SOUZA Matheus Kleber de Jesus1,FERREIRA Renata Cristina Mendes2,SILVA Irismara Sousa2,MACHADO Tallita Marques1,PINHEIRO Carlos Cleomir de Souza3,GUILHON-SIMPLICIO Fernanda1,KLEIN Andre2,PEREZ Andrea de Castro2,LIMA Emerson Silva1,MOURA Clarice de Carvalho Veloso1ORCID

Affiliation:

1. Universidade Federal do Amazonas, Brazil

2. Universidade Federal de Minas Gerais, Brazil

3. Instituto Nacional de Pesquisas da Amazônia - INPA, Brazil

Abstract

ABSTRACT The oil of Caryocar villosum is used in Amazonian folk medicine to treat pain and inflammatory conditions. So, we assessed the anti-inflammatory and antinociceptive properties of the ethanolic extract obtained from the fruit peels of this species. The acetic acid-induced writhing, carrageenan-induced mechanical hyperalgesia, formalin, carrageenan-induced paw edema and carrageenan-induced peritonitis tests were used on mice. The C. villosum ethanolic extract significantly inhibited the number of abdominal writhes, mechanical hyperalgesia and paw licking time in the second phase of the formalin test. At a dose of 300 mg kg-1, the extract also significantly reduced the volume of edema formed in the late phase and reduced the recruitment of leukocytes and neutrophils in the peritoneal cavity, as well as CXCL1 chemokine levels. It is suggested that the extract attenuates the leukocyte recruitment by inhibiting the CXCL1 activation. The peripheral antinociceptive activity occured through opioid pathway modulation because pretreatment with C. villosum ethanolic extract reversed the naltrexone-induced antinociception.

Publisher

FapUNIFESP (SciELO)

Subject

General Agricultural and Biological Sciences

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