Affiliation:
1. University 'La Sapienza', Italy
Abstract
Diagnosis and particularly follow-up of chronic inflammatory disorders could be often difficult in clinical practice. Indeed, traditional radiological techniques reveal only structural tissue alterations and are not able to monitor functional changes occurring in tissues affected by chronic inflammation. The continuous advances in the knowledge of the pathophysioloy of chronic disorders, combined with the progress of radiochemistry, led to the development of new specific radiolabelled agents for the imaging of chronic diseases. In this scenario, cytokines, due to their pivotal role in such diseases, represent good candidates as radiopharmaceuticals.
Reference32 articles.
1. Analysis of activated T cell infiltrates in rat renal allografts by gamma camera imaging after injection of 123-iodine-interleukin 2;Abbs I. C.;Transplant Immunology,1993
2. Comparison between 99mTc-HMPAO granulocyte and 99m-Tc-IL2 scintigraphy in Chron’s disease;Annovazzi A.;Eur. J. Nucl. Med.,1999
3. Radiolabelled interleukin-12 p40: A new radiopharmaceutical for imaging chronic TH1-mediated inflammation;Barone R.;Q. J. Nucl. Med.,1998
4. 99mTc-IL2 scintigraphy in patients with cutaneous melanoma: detection of lymphocytic infiltration;Barone R.;Eur. J. Nucl. Med.,1998
5. The role of nuclear medicine in infection and inflammation;Becker W.;The Lancet Infectious Diseases,2001
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