Reduction of liver mass due to malnutrition in rats: correlation with emaciation of animals and size of organs not inserted in the portal system

Author:

Parra Osório Miguel1,Hernandez-Blasquez Francisco Javier1,Silva Rubens Augusto Penteado de Sousa e1,Silva José Roberto Machado Cunha da1,Peduto Luigi1,Soares Magna Maltauro1,Saad William Abrão1,Saad Junior William Abrão1

Affiliation:

1. Universidade de São Paulo; Pontifícia Universidade Católica, Brazil

Abstract

We studied the effects of protein-energy malnutrition on the liver morphology of rats as compared to animal emaciation and to reduction in size of the organs not irrigated by splanchnic blood such as kidneys and spleen. The animals were divided into two groups, one of them fed ad libitum rate (N=10) and the other (N=14) receiving water but no food for 7 days, and the changes in animal weight, liver, kidney and spleen mass were determined. DNA and the protein/DNA ratio, as well as hepatocyte size, were determined in liver tissue. The liver decreased in mass (27.14%) at a significantly higher proportion (p<0.05) when compared to body emaciation (19.22%). Similar to the reduction in body weight, the masses of kidneys and spleen were reduced by 18.68% and 24.28%, respectively. The reduction in liver mass occurred due to hypoplasia and atrophy, i.e., a decrease in hepatocyte number and size, respectively. We conclude that there is a preferential consumption of liver protein in protein-energy malnutrition which is suggested to result from the additive action of the effects of overall consumption of organic reserves due to malnutrition proper and to the reduction of the hepatotrophic stimulus.

Publisher

FapUNIFESP (SciELO)

Subject

General Medicine

Reference53 articles.

1. The quantities of protein lost by the various organs and tissues of the body during a fast;ADDIS T.;J. Biol. Chem.,1936

2. Protein loss from liver during a two day fast;ADDIS T.;J. Biol. Chem.,1936

3. Hepatotrophic factors: basic concepts and clinical implications;BAKER A.L.;Acta Med. Scand.,1985

4. Diet and the insulin content of pancreas;BEST C.H.;J. Physiol.,1939

5. Portal and peripheral vein immunoreactive insulin concentrations before and after glucose infusion;BLACKARD W.G.;Diabetes,1970

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