Affiliation:
1. Universidade Federal de Minas Gerais
2. Universidade Federal de Ouro Preto
Abstract
Antigenic extracts from five Leishmania stocks were used to vaccinate C57BL/10 mice. The Leishvacin® and PH8 monovalent vaccine yielded the highest IFN-gamma levels in the supernatants of spleen cell culture from vaccinated animals. Each single strain immunized group showed evidence of protective immunity six months after the challenge with promastigotes of Leishmania (Leishmania) amazonensis. No differences were detected between the vaccinated groups. It can be concluded that vaccines composed of single Leishmania stocks can provide protection to C57BL/10 mice against L. (L.) amazonensis infection.
Subject
Infectious Diseases,Microbiology (medical),Parasitology
Reference47 articles.
1. Immune responses associated with susceptibility of C57BL/10 mice to Leishmania amazonensis;Afonso LCC;Infection and Immununity,1993
2. Immunopathology of experimental cutaneous leishmaniasis;Andrade ZA;American Journal of Pathology,1984
3. Controlled field trial against New World Cutaneous Leishmaniasis;Antunes CMF;International Journal of Epidemiology,1986
4. Transforming growth factor b as a virulence mechanism for Leishmania braziliensis;Barral A;Proceedings of the National Academy of Sciences of the United States of America,1993
5. Vaccination and immunity against oriental sore;Berberian DA;Transactions of the Royal Society of Tropical Medicine and Hygiene,1939
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