Affiliation:
1. Federal University of Alfenas, Brazil; Federal University of Alfenas, Brazil
2. Federal University of Alfenas, Brazil
Abstract
Polymorphism in solids is a common phenomenon in drugs, which can lead to compromised quality due to changes in their physicochemical properties, particularly solubility, and, therefore, reduce bioavailability. Herein, a bibliographic survey was performed based on key issues and studies related to polymorphism in active pharmaceutical ingredient (APIs) present in medications from the Farmácia Popular Rede Própria. Polymorphism must be controlled to prevent possible ineffective therapy and/or improper dosage. Few mandatory tests for the identification and control of polymorphism in medications are currently available, which can result in serious public health concerns.
Subject
General Pharmacology, Toxicology and Pharmaceutics
Reference246 articles.
1. Solid form screening ? a review;AALTONEN J.;Eur. J. Pharm. Biopharm,2009
2. Crystal structure of 6-((1-methyl-4-nitroimidazol-5-yl)thio) purine;ACHARYA K.R.;P. Indian AS-Chem. Sci.,1984
3. Analysing the crystal purity of mebendazole raw material and its stability in a suspension formulation;AGATONOVIC-KUSTRIN S.;Int. J. Pharm,2008
4. Powder diffractometric assay of two polymorphic forms of ranitidine hydrochloride;AGATONOVIC-KUSTRIN S.;Int. J. Pharm.,1999
5. Evaluation of polymorphs in cephalexin medicines by 13C solid state NMR;AGUIAR D.L.M.;Int. J. Pharm. Pharm. Sci.,2011
Cited by
43 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献