Diagnostic accuracy of 64 slice ct coronary angiography for diagnosing significant coronary artery stenosis

Abstract

Objective: To determine the diagnostic accuracy of 64 slice CT angiography in the detection of significant coronary artery stenosis in patients suspected to have coronary artery disease keeping invasive conventional coronary angiography as gold standard. Methods: The cross-sectional study was conducted at KRL Hospital, Islamabad and data was obtained during the period of six months from April 2014 to October 2014. All the patient of either gender from the age of 35 to 70years who had H/O angina and without any known CAD were included. CCTA and conventional invasive angiography (CIA) findings were recorded in every patient. Occlusion of >50% in coronary artery considered as positive angiography. Results: Among 135 patients 82.2% (n=111) of patients were males and 17.8% n=(24) were females. 63.7% (n=86) of patients were CCTA positive and 65.9% (n=89) of patients had disease on CIA. Sensitivity, specificity, PPV, NPV and accuracy were found to be 91.1%, 89.1%, 94.2%, 83.7% and 90.4% respectively. Conclusion: CCTA with improved spatial resolution and premedication with oral beta-blockade permits detection of coronary artery stenosis with high accuracy. Further large scale studies are needed in our setup to validate this technique in routine clinical practice.