Treatment of acute myeloid leukemia – a single center experience (2007–2013)

Abstract

Introduction: Mortality of acute myeloid leukemia is still 60–70% in young (<60 years) adults and 90% in elderly (≥60 years) patients. Aim: The aim of the authors was to analyse the outcome of treatment in their patients with acute myeloid leukemia. Method: From 2007 to 2013, 173 patients with acute myeloid leukemia were treated. Patients were classified according to the European LeukemiaNet prognostic guideline. Association between mortality and the type of acute myeloid leukemia (secundary or primary), dose of daunoblastin at induction of treatment, and the rate of minimal residual disease were investigated. Results: The 5-year survival probability was 25% in young adults and 2% in the elderly. The survival was significantly influenced by these prognostic factors. The 5-year survival rate was 50% in the young, favorable prognostic group. The 90 mg/m2daunoblastin dose was found to be beneficial. Addition of bortezomib to the standard induction protocol had an additional beneficial effect. Conclusions: The speed and depth of the response to induction therapy, and the initial white blood cell count had an apparent effect on survival. Orv. Hetil., 2014, 155(17), 653–658.