Carbapenem-resistant Klebsiella pneumoniae in the Balkans: Clonal distribution and associated resistance determinants

Author:

Chatzidimitriou Maria1ORCID,Kavvada Asimoula1,Kavvadas Dimitrios2,Kyriazidi Maria Anna2,Eleftheriadis Konstantinos1,Varlamis Sotirios1,Papaliagkas Vassilis1,Mitka Stella1

Affiliation:

1. Department of Biomedical Sciences, School of Health Sciences, International Hellenic University, Thessaloniki, Greece

2. Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece

Abstract

AbstractCarbapenems are considered to be among the last line antibiotics against extended-spectrum β-lactamase producing Enterobacterales. Carbapenem-resistant Klebsiella pneumoniae (CRKP) has been frequently reported and its spread in Europe is indisputable and poses an enormous threat to hospitalized patients which is of growing concern. This review aims to record prevalence of CRKP in the Balkan region and to review the current knowledge about this life-threatening pathogen. In this review, we summarize data about clinical isolates of carbapenem-resistant K. pneumoniae from Greece, Croatia, Romania, Bulgaria, Serbia, Slovenia, Montenegro, Bosnia-Herzegovina and Albania from published reports between 2000 and 2023. Among Balkan countries, Greece and Romania are the ones with the most reports about CRKP. Since 2007, KPCs are the dominant carbapenemases in both countries. KPC-2 and NDM-1-producing K. pneumoniae strains have been identified as the most frequent CRKP in Croatia, Bulgaria, Serbia, and Slovenia. OXA-48 enzyme has been identified in most Balkan countries. In addition, since 2018, CRKP sequence type 11 (ST11) seems to have replaced ST258 in Balkan Peninsula, while ST15 continues to thrive throughout the years. Not only efficacy of colistin against CRKP has decreased dramatically during the last ten years but colistin resistance mechanism is based on alterations of chromosomal mgrB gene, rather than the already known mcr genes.Moreover, ceftazidime-avibactam-resistant CRKP were detected mostly in Greece. Emergence of CRKP poses a severe threat to the Balkan countries. Due to the narrow therapeutic window, it is essential to prevent the spread of multiresistant K. pneumoniae strains.

Publisher

Akademiai Kiado Zrt.

Reference148 articles.

1. The characteristic of virulence, biofilm and antibiotic resistance of Klebsiella pneumoniae;Wang G,2020 Aug 28

2. Klebsiella pneumoniae as a key trafficker of drug resistance genes from environmental to clinically important bacteria;Wyres KL,2018 Oct

3. Genomic definition of hypervirulent and multidrug-resistant Klebsiella pneumoniae clonal groups;Bialek-Davenet S,2014 Nov

4. The global epidemiology of carbapenemase-producing Enterobacteriaceae;van Duin D,2017 May 19

5. OXA-48-like carbapenemases: the phantom menace;Poirel L,2012 Jul 1

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