Comparative E-cadherin and syndecan-1 protein expression in human and canine oral squamous cell carcinoma-Reference-Cited by-同舟云学术

Comparative E-cadherin and syndecan-1 protein expression in human and canine oral squamous cell carcinoma

Published:2024-01-09 Issue:3-4 Volume:71 Page:202-209
ISSN:0236-6290
Container-title:Acta Veterinaria Hungarica
language:
Short-container-title:AVet

Author:

Tabtieang Sirinun P.¹²,Paphussaro Weejarin²³,Rungsipipat Anudep²⁴,Kunnasut Nanthida²³,Ploypetch Sekkarin⁵,Phattarataratip Ekarat⁶,Suriyaphol Gunnaporn²³^ORCID

Affiliation:

1. Department of Veterinary Surgery, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand

2. Center of Excellence for Companion Animal Cancer, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand

3. Biochemistry Unit, Department of Physiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand

4. Department of Veterinary Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand

5. Department of Clinical Sciences and Public Health, Faculty of Veterinary Science, Mahidol University, Nakhon Pathom, Thailand

6. Department of Oral Pathology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand

Abstract

AbstractOral squamous cell carcinoma (OSCC) is a prevalent form of oral cancer in humans and dogs. The altered expression of cell adhesion molecules, including E-cadherin (CDH1) and syndecan-1 (SDC1), is involved in cancer progression. This study aimed to investigate the protein expression of CDH1 and SDC1 in early and late clinical stages of human and canine OSCC (hOSCC and cOSCC, respectively), using immunohistochemistry. Formalin-fixed and paraffin embedded tissue blocks were obtained from 21 hOSCC, 8 human normal gingiva, 26 cOSCC, and 13 canine normal gingiva. Clinical stages and histological subtypes of samples were evaluated. The results indicated that both human and canine OSCC exhibited reduced levels of CDH1 and SDC1 expression at the cell membrane regardless of clinical stage or histological subtype. Additionally, decreased levels of total SDC1 expression were observed in hOSCC compared with normal controls. In conclusion, this study demonstrates a similarity in the immunohistochemical expression of CDH1 and SDC1 between humans and dogs with OSCC, lending support to the potential use of dogs as a model for studying human head and neck squamous cell carcinoma.

Funder

Chulalongkorn University–Veterinary Science Research Fund

Publisher

Akademiai Kiado Zrt.

Link

https://akjournals.com/downloadpdf/journals/004/71/3-4/article-p202.xml

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